Zahavi J, Betteridge J D, Jones N A, Galton D J, Kakkar V V
Am J Med. 1981 Jan;70(1):59-64. doi: 10.1016/0002-9343(81)90412-5.
Plasma level of beta-thromboglobulin (beta TG), a useful marker of in vivo platelet "release reaction,"was determined by radioimmunoassay in 69 patients, with three types of primary hyperlipidemia (IIa, IIb, IV) and compared with the findings in age- and sex-matched healthy controls and 57 patients with established atherosclerosis and peripheral vascular disease. Malondialdehyde (MDA) formation, used for assessment of prostaglandin synthesis, was determined in 51 and plasma platelet factor 4 (PF4), measured by radioimmunoassay, in 48 of the patients with hyperlipidemia. Results were correlated to five serum lipids and lipoprotein levels in the patients with hyperlipidemia. beta TG was significantly increased in the patients with hyperlipidemia and peripheral vascular disease, compared to those in the controls (p < 0.001); it was significantly higher in the patients with hyperlipidemia than in those with peripheral vascular disease. PF4 and MDA formation were also increased in the patients with hyperlipidemia, and significantly higher levels of MDA were obtained in patients with type IIb and type IV hyperlipidemia than in those with type IIa hyperlipidemia (p < 0.02). beta TG and MDA correlated weakly with total serum cholesterol triglycerides and very low density lipoprotein-triglyceride. There was also a significant correlation between beta TG and PF4, and MDA production. These results indicate that in vivo platelet "release reaction" and MDA formation are increased in hyperlipidemic patients. The release reaction is more enhanced in those with hyperlipidemia than in the patients with peripheral vascular disease. They suggest that the abnormal platelet function is related to the elevated levels of serum lipids and lipoproteins in the hyperlipidemic patients and not only to the atherosclerotic changes associated with hyperlipidemia.
β-血小板球蛋白（β-TG）是体内血小板“释放反应”的一个有用标志物，通过放射免疫分析法测定了69例患有三种原发性高脂血症（IIa型、IIb型、IV型）患者的血浆水平，并与年龄和性别匹配的健康对照者以及57例已确诊动脉粥样硬化和外周血管疾病患者的结果进行了比较。在51例患者中测定了用于评估前列腺素合成的丙二醛（MDA）生成量，在48例高脂血症患者中通过放射免疫分析法测定了血浆血小板因子4（PF4）。结果与高脂血症患者的五种血清脂质和脂蛋白水平相关。与对照组相比，高脂血症和外周血管疾病患者的β-TG显著升高（p<0.001）；高脂血症患者的β-TG显著高于外周血管疾病患者。高脂血症患者的PF4和MDA生成量也增加，IIb型和IV型高脂血症患者的MDA水平显著高于IIa型高脂血症患者（p<0.02）。β-TG和MDA与血清总胆固醇、甘油三酯和极低密度脂蛋白-甘油三酯的相关性较弱。β-TG与PF4以及MDA生成之间也存在显著相关性。这些结果表明，高脂血症患者体内血小板“释放反应”和MDA生成增加。高脂血症患者的释放反应比外周血管疾病患者更增强。它们表明，异常的血小板功能与高脂血症患者血清脂质和脂蛋白水平升高有关，而不仅仅与高脂血症相关的动脉粥样硬化改变有关。
