大鼠脾细胞群体的特性。II. 抗原和同种异体细胞的激活作用。
Characterization of rat spleen cell populations. II. Activation by antigens and allogeneic cells.
作者信息
Rocha B, Freitas A A, Parrott D
出版信息
Immunology. 1980 Dec;41(4):825-32.
Abstract
Spleen cells from BN rats were separated in a discontinuous density gradient. Cells from different fractions were shown to be functionally diverse. Light cells were highly responsive in MLR, generated little killer activity and enhanced syngeneic recipient's IgM and IgG production in response to SRBC. Dense cells were unable to respond in MLR and suppress Ab response. Maximum killer activity was recovered from medium density fractions which were probably mixtures of helper and suppressor cells.
摘要
从BN大鼠中分离出的脾细胞在不连续密度梯度中进行分离。不同组分的细胞显示出功能多样性。轻细胞在混合淋巴细胞反应（MLR）中反应强烈，产生的杀伤活性很少，并能增强同基因受体对绵羊红细胞（SRBC）反应时的IgM和IgG产生。重细胞在MLR中无反应且能抑制抗体反应。最大杀伤活性从可能是辅助细胞和抑制细胞混合物的中等密度组分中获得。
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本文引用的文献
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The selective elimination of immunologically competent cells from bone marrow and lymphocyte cell mixtures. 3. In vitro test for detection of immunocompetent cells in fractionated mouse spleen cell suspensions and primate bone marrow suspensions.从骨髓和淋巴细胞混合液中选择性清除免疫活性细胞。3. 检测分级分离的小鼠脾细胞悬液和灵长类动物骨髓悬液中免疫活性细胞的体外试验。
Transplantation. 1969 Oct;8(4):422-34. doi: 10.1097/00007890-196910000-00014.
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Separation of stages in the development of the "T" cells involved in cell-mediated immunity.参与细胞介导免疫的 “T” 细胞发育阶段的分离。
J Exp Med. 1972 Jun 1;135(6):1375-91. doi: 10.1084/jem.135.6.1375.
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"Spontaneous" B cell activation due to loss of normal mouse serum suppressor.由于正常小鼠血清抑制因子缺失导致的“自发性”B细胞活化。
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