Bencko V, Benes B, Jechová S, Symon K
J Hyg Epidemiol Microbiol Immunol. 1980;24(4):389-95.
The effect of 3 diets with different proportion of milk proteins on retention of arsenic was studied in mice. Arsenic was administered via drinking water in concentration 50 mg As [III] per litre labelled with 74As in amount 2.96 MBq per 100 ml. After 2, 4, 8, 16 and 32 days of exposure the mice in groups of 6 each from all 3 experimental cohorts were decapitated and the content of 74As was determined in whole body, blood, liver, kidneys, spleen, lungs and heart by measuring of the activity in Gamma Scintillation Counter Tesla. From the intake of drinking water and amount of arsenic found in the experimental animals was calculated retention of arsenic in mice at different exposure intervals in all three diets. The values of arsenic found at the exposure intervals in examined materials of all three experimental cohorts were compared. The results obtained indicate that a milk diet has no adverse effect at exposure to arsenic in the sense of enhancing of its retention in mice at given experimental conditions. The found data seemed to suggest that the milk protein rich diet caused retardation of the increase of arsenic concentrations in blood, liver and kidneys that might lead at a lower exposure rate to a decrease in arsenic content in tissues of exposed animals.
研究了三种不同乳蛋白比例的饮食对小鼠砷潴留的影响。通过饮用水给予砷，浓度为每升50毫克三价砷，每100毫升中含有2.96兆贝可的74As。在暴露2、4、8、16和32天后，将来自所有三个实验队列的每组6只小鼠断头，并通过在伽马闪烁计数器特斯拉中测量活性来测定全身、血液、肝脏、肾脏、脾脏、肺和心脏中的74As含量。根据饮用水摄入量和实验动物体内发现的砷含量，计算出三种饮食在不同暴露间隔下小鼠的砷潴留情况。比较了所有三个实验队列在检查材料中暴露间隔时发现的砷值。所得结果表明，在给定实验条件下，乳类饮食在增加小鼠砷潴留方面对砷暴露没有不良影响。所发现的数据似乎表明，富含乳蛋白的饮食导致血液、肝脏和肾脏中砷浓度升高的速度减缓，这可能会在较低暴露率下导致暴露动物组织中砷含量降低。
