King D P, Srober S, Kaplan H S
J Immunol. 1981 Mar;126(3):1140-5.
Total lymphoid irradiation (TLI) was administered to mice as 17 fractions of 200 rads delivered to the major lymphoid organs. Spleen cells capable of suppressing the in vitro mixed leukocyte response (MLR) and in vivo graft-vs-host disease (GVHD) were found in mice after treatment with TLI. Suppression was not antigen specific and was markedly reduced by treatment of the spleen cells with anti-Thy-1.2 antiserum and complement. Suppressor activity declined with time after irradiation and disappeared within 30 to 40 days. The evidence suggests that the suppressor cells may prevent initial BM rejection and acute GVHD in allogeneic BM transplant recipients prepared with TLI.
对小鼠进行全身淋巴照射（TLI），以200拉德的剂量分17次照射主要淋巴器官。在用TLI治疗后的小鼠中发现了能够抑制体外混合淋巴细胞反应（MLR）和体内移植物抗宿主病（GVHD）的脾细胞。这种抑制作用不是抗原特异性的，并且在用抗Thy-1.2抗血清和补体处理脾细胞后明显减弱。照射后抑制活性随时间下降，并在30至40天内消失。证据表明，抑制细胞可能会防止在接受TLI预处理的异基因骨髓移植受者中出现初始骨髓排斥和急性GVHD。
