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1
Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function.全身淋巴照射诱导的免疫调节变化。II. 胸腺白血病抗原阳性和阴性抑制性T细胞的发育，其调节功能不同。
J Exp Med. 1981 Jul 1;154(1):13-23. doi: 10.1084/jem.154.1.13.
2
Immunoregulatory changes induced by total lymphoid irradiation (TLI). I. Appearance of a population of cells bearing the thymus leukemia (TL) surface antigen in the lymph nodes and spleen.全身淋巴照射（TLI）诱导的免疫调节变化。I. 淋巴结和脾脏中出现携带胸腺白血病（TL）表面抗原的细胞群体。
J Immunol. 1981 Sep;127(3):1085-9.
3
Suppression of cell-mediated immune responses after total lymphoid irradiation (TLI). I. Characterization of suppressor cells of the mixed lymphocyte reaction.全身淋巴照射（TLI）后细胞介导免疫反应的抑制。I. 混合淋巴细胞反应中抑制细胞的特征
J Immunol. 1984 Feb;132(2):971-8.
4
Induction and mechanism of tolerance to bovine serum albumin in mice given total lymphoid irradiation (TLI).经全身淋巴照射（TLI）的小鼠对牛血清白蛋白耐受性的诱导及机制
J Immunol. 1978 Oct;121(4):1400-4.
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Natural suppressor (NS) cells found in the spleen of neonatal mice and adult mice given total lymphoid irradiation (TLI) express the null surface phenotype.在接受全身淋巴照射（TLI）的新生小鼠和成年小鼠脾脏中发现的自然抑制细胞（NS细胞）表达无表面抗原表型。
J Immunol. 1984 Jan;132(1):101-10.
6
Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation.接受全身淋巴照射的成年小鼠或新生小鼠的脾细胞在混合淋巴细胞反应中具有相似的调节作用。一、在加入接受全身淋巴照射的成年小鼠脾细胞后，混合淋巴细胞反应中抗原特异性抑制细胞的产生。
J Exp Med. 1982 Aug 1;156(2):522-38. doi: 10.1084/jem.156.2.522.
7
Suppression of the mixed leukocyte response and of graft-vs-host disease by spleen cells following total lymphoid irradiation (TLI).全身淋巴照射（TLI）后脾细胞对混合淋巴细胞反应及移植物抗宿主病的抑制作用。
J Immunol. 1981 Mar;126(3):1140-5.
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Modulation of B and T cell subsets in mice treated with fractionated total lymphoid irradiation (TLI). IV. Expression of TL4-bearing cells in spleen and bone marrow of TLI-treated mice.分次全身淋巴照射（TLI）处理的小鼠中B细胞和T细胞亚群的调节。IV. TLI处理小鼠脾脏和骨髓中携带TL4细胞的表达。
J Immunol. 1983 Oct;131(4):1683-7.
9
Spleen cells from adult mice given total lymphoid irradiation (TLI) or from newborn mice have similar regulatory effects in the mixed leukocyte reaction (MLR). II. Generation of antigen-specific suppressor cells in the MLR after the addition of spleen cells from newborn mice.
J Immunol. 1982 Nov;129(5):1892-7.
10
Regulation of the immune response in experimental models of autoimmune disorders. II. Induction of suppressor cells of the mixed lymphocyte culture in adult (NZB x NZW)F1 mice using total lymphoid irradiation.自身免疫性疾病实验模型中免疫反应的调节。II. 使用全身淋巴照射在成年（新西兰黑鼠×新西兰白鼠）F1 小鼠中诱导混合淋巴细胞培养的抑制细胞
J Clin Lab Immunol. 1983 Jun;11(2):67-74.

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Path to clinical transplantation tolerance and prevention of graft-versus-host disease.临床移植耐受及移植物抗宿主病预防之路
Immunol Res. 2014 May;58(2-3):240-8. doi: 10.1007/s12026-014-8502-7.
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Evidence for the control of eosinophilia by the major histocompatibility complex in mice.小鼠主要组织相容性复合体对嗜酸性粒细胞增多症控制作用的证据。
Immunogenetics. 1983;17(2):167-77. doi: 10.1007/BF00364756.
3
Radiation and surgical stress induce a significant impairment in cellular immunity in patients with esophageal cancer.放疗和手术应激会导致食管癌患者的细胞免疫功能显著受损。
Jpn J Surg. 1989 Sep;19(5):535-43. doi: 10.1007/BF02471660.

本文引用的文献

1
A quantitative immunochemical measure of the primary interaction between I BSA and antibody.一种对牛血清白蛋白（BSA）与抗体之间主要相互作用的定量免疫化学测定方法。
J Infect Dis. 1958 Nov-Dec;103(3):239-62. doi: 10.1093/infdis/103.3.239.
2
Suppression of the mixed leukocyte response and of graft-vs-host disease by spleen cells following total lymphoid irradiation (TLI).全身淋巴照射（TLI）后脾细胞对混合淋巴细胞反应及移植物抗宿主病的抑制作用。
J Immunol. 1981 Mar;126(3):1140-5.
3
Mouse thymic iso-antigens.小鼠胸腺同种抗原。
Nature. 1966 Jan 29;209(5022):521-3. doi: 10.1038/209521b0.
4
A rapid method for the isolation of functional thymus-derived murine lymphocytes.一种分离功能性胸腺来源的小鼠淋巴细胞的快速方法。
Eur J Immunol. 1973 Oct;3(10):645-9. doi: 10.1002/eji.1830031011.
5
The splenic suppressor cell. II. Suppression of mixed lymphocyte reaction by thymus-dependent adherent cells.脾抑制细胞。II. 胸腺依赖性贴壁细胞对混合淋巴细胞反应的抑制作用。
J Immunol. 1974 Jul;113(1):140-4.
6
Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes.小鼠淋巴细胞功能的个体发生。II. 产生抗体能力的发育受T淋巴细胞调节。
J Exp Med. 1975 Jan 1;141(1):216-26. doi: 10.1084/jem.141.1.216.
7
Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.小鼠新生抑制性T细胞的Ly表型及作用机制。
J Exp Med. 1977 Jul 1;146(1):59-73. doi: 10.1084/jem.146.1.59.
8
Changes in suppressor mechanisms during postnatal development in mice.小鼠出生后发育过程中抑制机制的变化。
J Exp Med. 1978 Jan 1;147(1):87-97. doi: 10.1084/jem.147.1.87.
9
Regulatory mechanisms in cell-mediated immune responses. II. Comparison of culture-induced and alloantigen-induced suppressor cells in MLR and CML.细胞介导免疫反应中的调节机制。II. 混合淋巴细胞反应和细胞介导的淋巴细胞溶解中培养诱导的抑制细胞与同种抗原诱导的抑制细胞的比较。
J Immunol. 1977 May;118(5):1886-95.
10
In vitro generation of suppressor cell activity: suppression of in vitro induction if cell-mediated cytotoxicity.体外抑制细胞活性的产生：对体外诱导细胞介导的细胞毒性的抑制作用
J Immunol. 1976 Jan;116(1):167-77.

全身淋巴照射诱导的免疫调节变化。II. 胸腺白血病抗原阳性和阴性抑制性T细胞的发育，其调节功能不同。

Immunoregulatory changes induced by total lymphoid irradiation. II. Development of thymus-leukemia antigen-positive and -negative suppressor T cells that differ in their regulatory function.

作者信息

King D P, Strober S

出版信息

J Exp Med. 1981 Jul 1;154(1):13-23. doi: 10.1084/jem.154.1.13.

DOI:10.1084/jem.154.1.13
PMID:6454753
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2186386/
Abstract

BALB/c mice treated with total lymphoid irradiation (TLI) develop non-antigen-specific suppressor cells of the adoptive secondary antibody response and of the mixed leukocyte reaction. Suppressors of the adoptive anti-DNP response were eliminated by incubation of spleen cells with anti-Thy-1.2 or anti-thymus-leukemia (TL) antiserum and complement before cell transfer. Thymectomy before TLI prevented the appearance of the latter suppressor cells. On the other hand, suppressors of the MLR were eliminated by incubation of spleen cells with anti-Thy-1.2 but not anti-TL antiserum and complement. Thymectomy before TLI did not prevent their subsequent development. Thus, two subpopulations of suppressor T cells that differ in the expression of the TL surface antigen, dependence on the presence of the thymus, and in regulatory functions develop after TLI. The TL+, thymus-dependent cell suppresses the adoptive antibody response, and the TL-, thymus-independent cell suppresses the MLR.

摘要

接受全身淋巴照射（TLI）的BALB/c小鼠会产生对过继性二次抗体反应和混合淋巴细胞反应的非抗原特异性抑制细胞。在细胞转移前，通过将脾细胞与抗Thy-1.2或抗胸腺白血病（TL）抗血清及补体孵育，可消除过继性抗DNP反应的抑制细胞。TLI前进行胸腺切除可阻止后一种抑制细胞的出现。另一方面，通过将脾细胞与抗Thy-1.2而非抗TL抗血清及补体孵育，可消除混合淋巴细胞反应的抑制细胞。TLI前进行胸腺切除并不能阻止其随后的产生。因此，在TLI后会产生两个抑制性T细胞亚群，它们在TL表面抗原的表达、对胸腺存在的依赖性以及调节功能方面存在差异。TL+的胸腺依赖性细胞抑制过继性抗体反应，而TL-的胸腺非依赖性细胞抑制混合淋巴细胞反应。