Okulov V B, Vlasov N N, Anichkov N M
Biull Eksp Biol Med. 1980 Dec;90(12):719-21.
The epidermal G2 chalone-like substance of the rat skin may be determined by immunochemical methods only in squamous epithelia and it is revealed neither in mucosa of the urinary bladder, nor in urine of control rats. The antigenic activity of the chalone was revealed in 37 extracts of 56 tumors of the rat bladder. All antigen-containing tumors were found to be squamous cell carcinomas, transitional cell carcinomas with squamous cell metaplasia or possessed ultramicroscopic signs of squamous cell metaplasia appearing as "pure" transitional cell carcinomas under light microscope. The epidermal G2 chalone-like substance was present in urine of 7 out of 10 rats bearing the antigen-positive tumors of the urinary bladder.
大鼠皮肤的表皮G2类抑素样物质仅能用免疫化学方法在鳞状上皮中检测到，在对照大鼠的膀胱黏膜及尿液中均未发现。在56例大鼠膀胱肿瘤的37份提取物中发现了抑素的抗原活性。所有含抗原的肿瘤均为鳞状细胞癌、伴有鳞状化生的移行细胞癌，或在光学显微镜下表现为“单纯”移行细胞癌但具有鳞状化生超微结构特征的肿瘤。10只患有膀胱抗原阳性肿瘤的大鼠中，有7只的尿液中存在表皮G2类抑素样物质。
