Okulov V B, Zabezhinskiĭ M A
Biull Eksp Biol Med. 1980 Aug;90(8):248-9.
Epidermal G2 chalone was determined in induced rat lung tumors by the double immunodiffusion test or by immunoautoradiography. Epidermal chalone normally contained by keratinized tissues alone was detected in squamous cell lung carcinomas or adenomas with areas of squamous cell differentiation rather than in so-called pure adenocarcinomas. The antigen concentration correlated with the expansion of the areas of squamous cell differentiation. Thus the detection of epidermal G2 chalone can serve as marker of squamous cell metaplasia in the rat lung tissue.
通过双向免疫扩散试验或免疫放射自显影法测定诱导大鼠肺肿瘤中的表皮G2抑素。仅在角化组织中正常含有的表皮抑素在具有鳞状细胞分化区域的肺鳞状细胞癌或腺瘤中被检测到，而在所谓的纯腺癌中未检测到。抗原浓度与鳞状细胞分化区域的扩大相关。因此，表皮G2抑素的检测可作为大鼠肺组织中鳞状细胞化生的标志物。
