Anichkov N M, Vlasov N N, Okulov V B
Arkh Patol. 1981;43(4):82-4.
The presence of epidermal G2 chalone was investigated by different immunochemical methods in normal urothelium and in tumors of the urinary bladder induced in rats with N-butyl-N-butanol-(4)-nitrosamine. This chalone was not revealed in normal urothelium but found in 37 out of 56 tumors examined. In all these 37 tumors, squamous urothelial metaplasia was detected by electron or even light microscopy. The extent of morphological manifestations of squamous metaplasia showed a definite correlation with the concentration of chalone in tissue extracts. The method used may be applied as a subsidiary test for the determination of focal squamous metaplasia in biopsy material of human urothelial tumors which is of importance for prognosis of the disease.
采用不同免疫化学方法，对正常尿路上皮以及用N-丁基-N-丁醇-（4）-亚硝胺诱发的大鼠膀胱肿瘤中的表皮G2抑素进行了研究。在正常尿路上皮中未发现这种抑素，但在所检查的56个肿瘤中有37个发现了它。在所有这37个肿瘤中，通过电子显微镜甚至光学显微镜均检测到鳞状尿路上皮化生。鳞状化生的形态学表现程度与组织提取物中抑素的浓度呈明确的相关性。所使用的方法可作为一种辅助检测手段，用于确定人尿路上皮肿瘤活检材料中的局灶性鳞状化生，这对疾病的预后具有重要意义。
