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[血糖正常、轻度异常及确诊为病理性糖耐量异常受试者的心血管疾病风险状况]

[The cardiovascular risk profile of subjects with normal, marginally disordered and proven pathological glucose tolerance].

作者信息

Schneider H, Burrmann H, Ziegelasch H J

出版信息

Z Gesamte Inn Med. 1978 Feb 15;33(4):110-2.

PMID:645141
Abstract

In 1.035 persons with reduced glucose tolerance (borderline diabetics, diabetic biophan G test admissions, spontaneous admissions and diabetics treated already for a longer time) the cardiovascular factors of risk over-weight (Broca-weight greater than or equal to 110%), hypertension (RR greater than or equal to 160/and/or 95 Torr), hypertriglyceridaemia (greater than or equal to 200 mg/100 ml), hypercholesterolaemia (greater than or equal to 300 mg/100 ml) and hyperuricaemia (greater than or equal to 6.5 mg/100 ml in males and 6.0 mg/100 ml in females) were determined and compared with the frequency of the same danger indicators of 255 persons with certainly normal glucose tolerance. Taking into consiteration the reduction of the glucose tolerance as cardiovascular factor of risk the glucosuria test admissions with 3.48 factor of risk/proband had no less factors of risk than the spontaneous diabetic admissions (3.29 factor of risk/proband). Already the borderline diabetic differed in the frequency of overweight, hypertension and hypertriglyceridaemia significantly (p less than 0.01) from the normal case of the same age. Thus the glucose tolerance disturbed in its limit deserves increased consideration from the diabetological as well as from the cardiological point of view.

摘要

在1035名糖耐量降低者(临界糖尿病患者、糖尿病生物酚G试验入院者、自发入院者以及已接受较长时间治疗的糖尿病患者)中,测定了超重(布罗卡体重≥110%)、高血压(收缩压≥160和/或舒张压≥95托)、高甘油三酯血症(≥200毫克/100毫升)、高胆固醇血症(≥300毫克/100毫升)和高尿酸血症(男性≥6.5毫克/100毫升,女性≥6.0毫克/100毫升)等心血管危险因素,并与255名糖耐量肯定正常者的相同危险指标出现频率进行了比较。将糖耐量降低视为心血管危险因素,尿糖试验入院者的风险因素为3.48(风险因素/受检者),并不少于自发糖尿病入院者(3.29风险因素/受检者)。临界糖尿病患者在超重、高血压和高甘油三酯血症的出现频率上与同年龄正常人群相比已有显著差异(p<0.01)。因此,从糖尿病学和心脏病学角度来看,糖耐量在临界状态受到干扰值得更多关注。

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