Uff J S, Mitcheson H D, Pussell B A, Brill M, Castro J E
J Pathol. 1981 Feb;133(2):89-105. doi: 10.1002/path.1711330202.
Mice given a killed suspension of Corynebacterium parvum (C.p.) developed nephritis as part of an immune complex disease. The nephritis was dose-related. After a single dose of 70 microgram (a human-equivalent dose) or of 466 microgram there was a mesangiopathic glomerulonephritis and after repeated human-equivalent doses there was a mesangiocapillary glomerulonephritis. Antibodies to C.p. increased and circulating immune complexes were detected. Mice receiving repeated doses also developed an arteritis. Study of this model may help in the understanding of human immune complex disease and the pathogenesis of glomerulonephritis.
给小鼠注射细小棒状杆菌（C.p.）的灭活悬液后，会引发肾炎，这是免疫复合物疾病的一部分。肾炎与剂量相关。单次注射70微克（相当于人类剂量）或466微克后，会出现系膜增生性肾小球肾炎，反复给予相当于人类的剂量后，则会出现系膜毛细血管性肾小球肾炎。针对C.p.的抗体增加，并且检测到循环免疫复合物。接受反复剂量注射的小鼠还会出现动脉炎。对该模型的研究可能有助于理解人类免疫复合物疾病以及肾小球肾炎的发病机制。
