用链球菌疫苗在兔身上诱发的实验性免疫性肾小球肾炎。
Experimental immune glomerulonephritis induced in the rabbit with streptococcal vaccine.
作者信息
Bellon B, Kuhn J, Ayed K, Girard J F, Druet P
出版信息
Clin Exp Immunol. 1979 Aug;37(2):239-46.
Abstract
Heavy C3 glomerular deposits were observed in rabbits injected intravenously with C5 streptococcal vaccine. Immunoglobulin deposits appeared later in a few rabbits. Although some data favour the presence of circulating immune complexes during the course of this glomerulonephritis, no evidence for their initiating role could be demonstrated. Streptococcal components are known to activate the alternative pathway of complement. It is suggested that complexes made of streptococcal components and activated C3 might deposit in glomerular tufts.
摘要
在静脉注射C5链球菌疫苗的兔子中观察到重度C3肾小球沉积物。免疫球蛋白沉积物在少数兔子中出现得较晚。尽管一些数据支持在这种肾小球肾炎过程中存在循环免疫复合物，但没有证据表明它们具有起始作用。已知链球菌成分可激活补体替代途径。有人提出，由链球菌成分和活化的C3组成的复合物可能沉积在肾小球丛中。
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