Randazzo B, Pfeffer P, Hirschberg T, Hirschberg H
J Clin Lab Immunol. 1980 Nov;4(3):175-80.
The effects of the steroid methylprednisolone (MP) on the induction of cytotoxic or suppressive lymphocytes in human mixed lymphocyte cultures (MLC) have been examined. Concentrations of MP sufficient to inhibit both the cellular proliferation and the generation of cytotoxic lymphocytes in MLC appeared to have very little effect on the induction of suppressor cells in these cultures. In fact, over a certain dosage range of MP an increased number of suppressor cells appeared to be generated. Moreover, low concentrations of MP greatly potentiated the effects of alloantigen induced suppressor cells but had little or no effect on the action of cytotoxic lymphocytes as measured in the cell mediated lympholysis assay. It seems therefore that MP has an opposing effect both on the generation and function of suppressor or cytotoxic lymphocytes induced by allogeneic cells.
已研究了类固醇甲泼尼龙（MP）对人混合淋巴细胞培养物（MLC）中细胞毒性或抑制性淋巴细胞诱导的影响。足以抑制MLC中细胞增殖和细胞毒性淋巴细胞生成的MP浓度，似乎对这些培养物中抑制性细胞的诱导影响很小。事实上，在MP的特定剂量范围内，似乎会产生更多数量的抑制性细胞。此外，低浓度的MP极大地增强了同种异体抗原诱导的抑制性细胞的作用，但对细胞介导的淋巴细胞溶解试验中所测定的细胞毒性淋巴细胞的作用几乎没有影响或没有影响。因此，MP似乎对同种异体细胞诱导的抑制性或细胞毒性淋巴细胞的生成和功能具有相反的作用。
