Tsokos G C, Christian C B, Balow J E
Immunology. 1982 Sep;47(1):85-90.
Experiments were performed to examine whether the concanavalin A (Con A)- induced suppressor cells of several in vitro T- and B-lymphocyte functions constitute a functionally unique cell population. This study included simultaneous studies of three different assays of suppression of T- and B-lymphocyte functions. We found that Con-A-induced suppressor cells which inhibit the allogeneic mixed lymphocyte reaction (MLR) and the pokeweed mitogen-induced, plaque-forming cell (PEC) response are radiation sensitive at doses greater than 1000 rad, but corticosteroid resistant, while those suppressing allogeneic cell-mediated lympholysis (CML) are both radiation and corticosteroid resistant. These studies indicate either that Con-A-induced suppressor cells include heterogeneous populations which are differentially sensitive to corticosteroids and radiation, or that functionally distinct suppressor mechanisms are variably sensitive to these agents.
进行实验以检验伴刀豆球蛋白A（Con A）诱导的几种体外T和B淋巴细胞功能的抑制细胞是否构成一个功能独特的细胞群体。本研究包括对T和B淋巴细胞功能抑制的三种不同检测方法的同步研究。我们发现，抑制同种异体混合淋巴细胞反应（MLR）和商陆有丝分裂原诱导的空斑形成细胞（PEC）反应的Con - A诱导抑制细胞在剂量大于1000拉德时对辐射敏感，但对皮质类固醇有抗性，而抑制同种异体细胞介导的淋巴细胞溶解（CML）的细胞对辐射和皮质类固醇均有抗性。这些研究表明，要么Con - A诱导的抑制细胞包括对皮质类固醇和辐射敏感性不同的异质群体，要么功能不同的抑制机制对这些药物的敏感性不同。
