红细胞衰老过程中膜糖蛋白的生化研究。
Biochemical studies of membrane glycoproteins during red cell aging.
作者信息
Platt D, Norwig P
出版信息
Mech Ageing Dev. 1980 Sep-Oct;14(1-2):119-26. doi: 10.1016/0047-6374(80)90110-4.
(1) There is a significant decrease of ATPase activities in red cell membranes with increasing age of the donor. (2) A comparison of blood groups A and O relates the higher ATPase activities of young donors to blood group A. (3) Membrane ATPase activities reveal an age-dependent decrease in young and old donors with blood group A. (4) There is an age-dependent decrease of the N-acetylneuraminic acid concentration of glycophorin. (5) The galactose content of glycophorin only increases in blood group A. (6) There are no age-dependent changes of the exposed galactose. (7) The experiments so far reveal an increase of IgG absorption to old glycophorin.
(1) 随着供血者年龄的增加，红细胞膜中ATP酶活性显著降低。(2) A型血和O型血的比较表明，年轻供血者中较高的ATP酶活性与A型血有关。(3) 膜ATP酶活性显示，A型血的年轻和年老供血者中均存在与年龄相关的降低。(4) 血型糖蛋白的N-乙酰神经氨酸浓度存在与年龄相关的降低。(5) 血型糖蛋白的半乳糖含量仅在A型血中增加。(6) 暴露的半乳糖没有与年龄相关的变化。(7) 迄今为止的实验表明，老年血型糖蛋白的IgG吸附增加。
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