Kahane I, Ben-Chetrit E, Shifter A, Rachmilewitz E A
Biochim Biophys Acta. 1980 Feb 15;596(1):10-7. doi: 10.1016/0005-2736(80)90166-2.
The sialic acids content of glycophorin of thalassemic erythrocyte membranes is about 25% lower than in glycophorin of normal erythrocyte membranes. Glycophorin extracted from old thalassemic erythrocytes separated by density centrifugation, has about half the sialic acids content found in glycophorin extracted from young thalassemic erythrocytes. Possible sialidase activty was sought in the plasma and erythrocyte membranes of thalassemic erythrocytes. No increased sialidase activity was detected in the plasma of the patients as compared to that of normal donors. Thus, other sites for sialidase activity, or other possibilities have to be explored to account for the increased sialic acid hydrolysis of glycophorin of the thalassemic erythrocytes.
地中海贫血红细胞膜上血型糖蛋白的唾液酸含量比正常红细胞膜上血型糖蛋白的唾液酸含量低约25%。从通过密度离心分离出的衰老地中海贫血红细胞中提取的血型糖蛋白，其唾液酸含量约为从年轻地中海贫血红细胞中提取的血型糖蛋白中唾液酸含量的一半。研究了地中海贫血红细胞的血浆和红细胞膜中可能存在的唾液酸酶活性。与正常供体相比，未检测到患者血浆中唾液酸酶活性增加。因此，必须探索唾液酸酶活性的其他位点或其他可能性，以解释地中海贫血红细胞血型糖蛋白中唾液酸水解增加的现象。
