Magalov Sh I, Dadali E L
Zh Nevropatol Psikhiatr Im S S Korsakova. 1980;80(8):1158-63.
Excretion of free catecholamines and dopamine was examined in 18 patients with Huntington's chorea and in their phenotypically healthy relatives (16 persons). A relationship between the level of the dopamine excretion and the degree of the hyperkinetic disturbances has been revealed. Part of the healthy relatives showed a substantial increase in dopamine excretion. It is suggested that dopamine metabolism disturbances play the leading role in the disease development, and that it would be wise to use therapeutic agents acting upon the striatum small cells and dopaminergic receptors.
对18例亨廷顿舞蹈症患者及其表型健康的亲属（16人）进行了游离儿茶酚胺和多巴胺排泄情况的检查。已发现多巴胺排泄水平与运动机能亢进紊乱程度之间存在关联。部分健康亲属的多巴胺排泄量大幅增加。研究表明，多巴胺代谢紊乱在疾病发展中起主导作用，使用作用于纹状体小细胞和多巴胺能受体的治疗药物可能是明智的。
