Vasil'ev V N, Matlina E Sh
Vopr Med Khim. 1977 May-Jun(3):332-8.
Administration of 1-DOPA into healthy persons increased its excretion with urine and elevated the adrenaline secretion. The increase of catecholamines excretion was not observed in aged patients with hypertension; the data obtained suggest that the synthesis of catecholamines with utilization of DOPA was inhibited. In patients with ulcerous disease excretion of 1-DOPA was not increased after its administration, but secretion of catecholamines was decreased during the day time. Under ulcerous disease 1-DOPA appears to be used in process unrelated to synthesis of catecholamines.
给健康人服用左旋多巴会增加其尿排泄量并提高肾上腺素分泌。在老年高血压患者中未观察到儿茶酚胺排泄量增加；所获得的数据表明，利用左旋多巴合成儿茶酚胺的过程受到了抑制。在溃疡病患者中，服用左旋多巴后其排泄量并未增加，但白天儿茶酚胺的分泌量却减少了。在溃疡病情况下，左旋多巴似乎用于与儿茶酚胺合成无关的过程。
