Shinozawa S, Araki Y, Oda T
Acta Med Okayama. 1980 Sep;34(4):255-61. doi: 10.18926/AMO/30522.
The effects of coenzyme Q10 (Co Q10) on potassium ion release, membrane potential and fluidity of rabbit red blood cells were studied. Co Q10 inhibited the increased potassium ion release induced by cetylamine or lysolecithin from the cells. Co Q10 slightly decreased the membrane potential monitored by changes in fluorescence intensity of cyanine dye, 3,3'-dipropyl-2,2'-thiodicarbocyanine iodide [diS-C3-(5)], and also slightly decreased the membrane fluidity measured by using 1,6-diphenyl-1,3,5-hexatriene (DPH). These effects of Co Q10 on the membrane are considered to be due to its membrane stabilizing activity by interaction with lipid bilayers of the membrane.
研究了辅酶Q10（Co Q10）对兔红细胞钾离子释放、膜电位和流动性的影响。Co Q10抑制了十六胺或溶血卵磷脂诱导的细胞内钾离子释放增加。Co Q10使通过花菁染料3,3'-二丙基-2,2'-硫代二碳菁碘化物[diS-C3-(5)]荧光强度变化监测的膜电位略有降低，并且也使使用1,6-二苯基-1,3,5-己三烯（DPH）测量的膜流动性略有降低。Co Q10对膜的这些作用被认为是由于其通过与膜的脂质双层相互作用而具有的膜稳定活性。
