Fritsch R, Heyer R, Freyschmidt J
Rofo. 1981 Jan;134(1):56-61. doi: 10.1055/s-2008-1056301.
Anticonvulsant therapy can lead to severe rachitic changes in the skeleton which closely resemble renal osteopathy. In addition to apparent widening of the epiphyseal plate, there are changes in the cortex of the long bones. Within four to six weeks of the commencement of vitamin D therapy, recalcification of the poorly recognised. Since the changes are best seen in the hand, further examinations of the skeleton are only indicated if there are positive findings in the hand.
抗惊厥治疗可导致骨骼出现严重的佝偻病样改变,这与肾性骨病极为相似。除了骨骺板明显增宽外,长骨皮质也有变化。在开始维生素D治疗后的四至六周内,骨骼重新钙化情况难以识别。由于手部的变化最为明显,只有当手部检查有阳性发现时,才需要进一步对骨骼进行检查。