通过改进的X射线密度测定技术对抗惊厥药物引起的骨质脱矿进行定量测定。
A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.
作者信息
Wolschendorf K, Vanselow K, Möller W D, Schulz H
出版信息
Neuroradiology. 1983;25(5):315-8. doi: 10.1007/BF00439210.
PMID:6646409
Abstract
Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.
摘要
采用微机辅助密度计系统，对88例癫痫患者进行了抗惊厥药物对骨矿物质含量影响的定量研究。结果表明，骨矿物质含量随治疗时间的延长而显著降低。发现苯妥英（DPH）单一疗法每年降低约1.2%，DPH加苯巴比妥联合疗法和DPH加卡马西平联合疗法分别为每年1.8%和2.0%。
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