Pavlova S I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1978;78(3):409-12.
The author studied changes of the coagulative blood system in patients with atherosclerotic and senile dementia (82 cases). In cases with simple forms of senile dementia a tendency towards hypercoagulability was established (an increased formation of thrombin, the amount of fibrinogen content). However, this group demonstrated a defensive activation of the anticoagulative system, sufficient to maintain an equilibrium in the whole system of hemocoagulation. An exhaustion of compensation may lead to stasis and microthrombosis in the smallest vessels and capillaries, which indicates to the pathogenetical significance of changes in the coagulative blood properties.
作者研究了82例动脉粥样硬化性和老年性痴呆患者凝血系统的变化。在单纯型老年性痴呆病例中，发现有高凝倾向（凝血酶形成增加、纤维蛋白原含量增多）。然而，该组患者抗凝系统出现防御性激活，足以维持整个血液凝固系统的平衡。代偿功能耗竭可能导致最小血管和毛细血管内出现血流淤滞和微血栓形成，这表明血液凝血特性变化具有致病学意义。
