在人类脑脊液中测量的单胺代谢产物在中枢神经系统中的起源部位。
Sites of origin in the central nervous system of monoamine metabolites measured in human cerebrospinal fluid.
作者信息
Garelis E, Sourkes T L
出版信息
J Neurol Neurosurg Psychiatry. 1973 Aug;36(4):625-9. doi: 10.1136/jnnp.36.4.625.
Abstract
The concentrations of homovanillic acid (HVA) and 5-hydroxyindole-acetic acid (5-HIAA) were measured in five cases with partial or complete block of CSF circulation, at various levels. Determinations were made in both a lumbar and a cisternal, or `mixed', sample obtained during pneumoencephalography. Most of the HVA appears to enter the ventricular system at the lateral ventricles, whereas much of the 5-HIAA in CSF originates in lower neuronal structures, including the spinal cord. The spinal contribution to the 5-HIAA content of lumbar CSF is of the order of 23-37%.
摘要
对5例不同程度脑脊液循环部分或完全受阻的患者，测定了高香草酸（HVA）和5-羟吲哚乙酸（5-HIAA）的浓度。在气脑造影期间获取的腰椎和脑池或“混合”样本中进行了测定。大部分HVA似乎在侧脑室进入脑室系统，而脑脊液中的大部分5-HIAA起源于较低的神经结构，包括脊髓。脊髓对腰椎脑脊液中5-HIAA含量的贡献约为23%-37%。
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