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人IgM类风湿因子对小鼠被动血清病中肾小球免疫复合物沉积的影响。

The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse.

作者信息

Ford P M, Kosataka I

出版信息

Immunology. 1982 Aug;46(4):761-8.

PMID:6213554
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1555479/
Abstract

The results of experiments reported in this paper show that intravenously injected human IgM rheumatoid factor binds in vivo to immune complexes previously deposited in mouse glomerulus. Prior injection of human IgM rheumatoid factor does not interfere with glomerular deposition of passively administered immune complexes. Evidence is presented to show that rheumatoid factor once attached to glomerular bound immune complexes is able to act as an immunoabsorbent and to bind further circulating complexes.

摘要

本文报道的实验结果表明，静脉注射的人IgM类风湿因子在体内与先前沉积于小鼠肾小球的免疫复合物结合。预先注射人IgM类风湿因子并不干扰被动给予的免疫复合物在肾小球的沉积。有证据表明，一旦类风湿因子附着于肾小球结合的免疫复合物，它就能作为一种免疫吸附剂并结合更多循环中的复合物。

相似文献

1
The effect of human IgM rheumatoid factor on renal glomerular immune complex deposition in passive serum sickness in the mouse.人IgM类风湿因子对小鼠被动血清病中肾小球免疫复合物沉积的影响。
Immunology. 1982 Aug;46(4):761-8.
2
In situ immune complex formation in the mouse glomerulus: reactivity with human IgM rheumatoid factor and the effect on subsequent immune complex deposition.小鼠肾小球原位免疫复合物的形成：与人IgM类风湿因子的反应性及其对后续免疫复合物沉积的影响。
Clin Exp Immunol. 1983 Feb;51(2):285-91.
3
Cationised IgM rheumatoid factor: in-vivo glomerular localization and immunoabsorptive capacity in the mouse.阳离子化IgM类风湿因子：在小鼠体内的肾小球定位及免疫吸附能力
Clin Exp Immunol. 1985 Oct;62(1):150-8.
4
Effect of human IgM rheumatoid factor on the glomerular site of localization of passively administered immune complexes in mice.人IgM类风湿因子对被动给予的免疫复合物在小鼠肾小球定位部位的影响。
Immunology. 1984 Oct;53(2):395-8.
5
Interaction of rheumatoid factor with immune complexes in experimental glomerulonephritis--possible role of antiglobulins in chronicity.类风湿因子与实验性肾小球肾炎中免疫复合物的相互作用——抗球蛋白在慢性化中的可能作用
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6
Induction of circulating immune complexes and their renal localization after acute or chronic polyclonal B-cell activation in mice.小鼠急性或慢性多克隆B细胞活化后循环免疫复合物的诱导及其在肾脏中的定位。
Kidney Int Suppl. 1982 May;11:S29-38.
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Removal of glomerular deposits induced by either preformed immune complexes or by a chronic immune complex model in NZB/W mice.去除由预先形成的免疫复合物或NZB/W小鼠慢性免疫复合物模型诱导产生的肾小球沉积物。
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Immunology. 1980 Oct;41(2):303-11.
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Glomerulonephritis: the use of grafted hybridomas to investigate the role of epitope density, antibody affinity and antibody isotype in active serum sickness.肾小球肾炎：利用移植杂交瘤研究表位密度、抗体亲和力及抗体同种型在活动性血清病中的作用
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A mechanism of enhancement of immune complex deposition following in situ immune complex formation in the mouse glomerulus.小鼠肾小球原位免疫复合物形成后免疫复合物沉积增强的机制。
Immunology. 1981 Jul;43(3):433-9.

引用本文的文献

1
Rheumatoid factor in patients with systemic lupus erythematosus.系统性红斑狼疮患者的类风湿因子
Clin Rheumatol. 1996 May;15(3):312-3. doi: 10.1007/BF02229717.
2
In situ immune complex formation in the mouse glomerulus: reactivity with human IgM rheumatoid factor and the effect on subsequent immune complex deposition.小鼠肾小球原位免疫复合物的形成：与人IgM类风湿因子的反应性及其对后续免疫复合物沉积的影响。
Clin Exp Immunol. 1983 Feb;51(2):285-91.
3
Cationised IgM rheumatoid factor: in-vivo glomerular localization and immunoabsorptive capacity in the mouse.

本文引用的文献

1
INHIBITION OF COMPLEMENT FIXATION BY HUMAN SERUM. II. THE ACTIVITY OF A GAMMA-LM GLOBULIN AND RHEUMATOID FACTOR IN COMPLEMENT FIXATION REACTIONS.人血清对补体结合的抑制作用。II. γ-LM球蛋白和类风湿因子在补体结合反应中的活性。
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Serum responses in rheumatoid arthritis.类风湿关节炎中的血清反应。
Am J Med. 1959 Apr;26(4):596-613. doi: 10.1016/0002-9343(59)90281-5.
3
The effect of in situ formation of antigen-antibody complexes in the glomerulus on subsequent glomerular localization of passively administered immune complexes.
阳离子化IgM类风湿因子：在小鼠体内的肾小球定位及免疫吸附能力
Clin Exp Immunol. 1985 Oct;62(1):150-8.
4
Rheumatoid factor in rheumatoid arthritis associated renal disease and in lupus nephritis.类风湿性关节炎相关肾病和狼疮性肾炎中的类风湿因子。
Ann Rheum Dis. 1986 Jun;45(6):508-11. doi: 10.1136/ard.45.6.508.
5
Glomerular lesions induced in the rabbit by physicochemically altered homologous IgG.经物理化学改变的同源免疫球蛋白G在兔体内诱导产生的肾小球病变
Am J Pathol. 1992 Mar;140(3):581-600.
肾小球内原位形成的抗原-抗体复合物对随后被动给予的免疫复合物在肾小球定位的影响。
Immunology. 1980 Mar;39(3):337-44.
4
A mechanism of enhancement of immune complex deposition following in situ immune complex formation in the mouse glomerulus.小鼠肾小球原位免疫复合物形成后免疫复合物沉积增强的机制。
Immunology. 1981 Jul;43(3):433-9.
5
Cryoglobulinemia--a clinical and laboratory study. II. Cryoglobulins with rheumatoid factor activity.冷球蛋白血症——一项临床与实验室研究。II. 具有类风湿因子活性的冷球蛋白
Am J Med. 1966 Jun;40(6):837-56. doi: 10.1016/0002-9343(66)90200-2.
6
Glomerular localization of aggregated protein in mice; effect of strain difference and relationship to systemic macrophage function.小鼠中聚集蛋白的肾小球定位；品系差异的影响及其与全身巨噬细胞功能的关系。
Br J Exp Pathol. 1975 Aug;56(4):307-13.
7
Complement fixation by rheumatoid factor.类风湿因子介导的补体固定
J Clin Invest. 1975 Mar;55(3):437-45. doi: 10.1172/JCI107949.
8
The molecular basis of self-association of IgG-Rheumatoid factors.IgG类风湿因子自我缔合的分子基础。
J Immunol. 1975 Aug;115(2):365-73.
9
Enhancement by IgM rheumatoid factor of in vitro ingestion by macrophages and in vivo clearance of aggregated IgG or antigen-antibody complexes.IgM类风湿因子对巨噬细胞体外摄取及体内清除聚集IgG或抗原-抗体复合物的增强作用。
Eur J Immunol. 1978 Apr;8(4):279-85. doi: 10.1002/eji.1830080412.
10
Renal localization of antiglobulins in glomerulonephritis and after renal transplantation.抗球蛋白在肾小球肾炎及肾移植后的肾脏定位
Arthritis Rheum. 1977 May;20(4):947-61. doi: 10.1002/art.1780200407.