Ford P M, Kosatka I
Clin Exp Immunol. 1983 Feb;51(2):285-91.
An in situ model of immune complex formation in the mouse was utilized to study the interaction of human IgM rheumatoid factor (RF) with glomerular bound immune complexes (IC). Prior intravenous injection of RF did not interfere with in situ IC formation, but reacted with complexes once formed. RF injected after formation of in situ IC was deposited in the same distribution as the complexes and was capable both in vivo and in vitro of acting as an immunoabsorbent and binding IC with the same antibody species as the in situ IC, but which had a different antigen component. The potential for this in situ immunoabsorbent activity of RF in the pathogenesis of the chronicity of the lesion in glomerulonephritis is discussed.
利用小鼠免疫复合物形成的原位模型来研究人IgM类风湿因子（RF）与肾小球结合免疫复合物（IC）的相互作用。预先静脉注射RF并不干扰原位IC的形成，但会与一旦形成的复合物发生反应。在原位IC形成后注射的RF以与复合物相同的分布沉积，并且在体内和体外都能够作为免疫吸附剂，与与原位IC相同抗体种类但具有不同抗原成分的IC结合。本文讨论了RF这种原位免疫吸附活性在肾小球肾炎病变慢性化发病机制中的可能性。
