Lavelle K J, Durland B D, Yum M N
J Lab Clin Med. 1981 Aug;98(2):195-205.
The effect of anti-M IgG on acute IC GN was assessed in rabbits. Nephritis was induced in sensitized animals with BSA. Anti-M IgG and the other immunoglobulins given to the various groups were administered by intra-aortic injection at the orifice of the left renal artery to avoid pulmonary sequestration of the antibodies. The animals were nephrectomized on the right to permit unilateral renal perfusion. The immunoglobulins were given to the study groups every 8 hr for 4 days, which corresponded to the period of IC formation and deposition in this model. Renal arteria perfusion with anti-M IgG reduced glomerular cellularity and preserved renal function. The groups given the other immunoglobulins were not afforded the same protection.
在兔子身上评估了抗-M IgG对急性免疫复合物性肾小球肾炎（IC GN）的作用。用牛血清白蛋白（BSA）在致敏动物中诱发肾炎。将抗-M IgG和给予不同组别的其他免疫球蛋白通过主动脉内注射在左肾动脉开口处给药，以避免抗体在肺部滞留。对动物进行右侧肾切除术以允许单侧肾脏灌注。每8小时给研究组注射免疫球蛋白，持续4天，这与该模型中免疫复合物形成和沉积的时期相对应。用抗-M IgG进行肾动脉灌注可减少肾小球细胞数量并保留肾功能。给予其他免疫球蛋白的组未获得同样的保护。
