Caligaris-Cappio F, Bergui L, Tesio L, Ziano R, Camussi G
Clin Exp Immunol. 1985 Jan;59(1):185-9.
The lineage and distribution of mononuclear cells infiltrating the kidneys of patients with systemic lupus erythematosus (SLE) have been investigated in cryostat tissue sections of biopsies from 11 patients. The use of heterologous antisera and monoclonal antibodies has revealed that: B lymphocytes and plasma cells are virtually absent in SLE kidney specimens; The vast majority of mononuclear cells which infiltrate the interstitium are activated (HLA-Dr+) T cells (Leu 4+) presenting the helper (Leu 3+) phenotype; T cells are absent in the glomeruli, where HLA-Dr+, SIgM-, Leu 4- elements with a macrophage like appearance can be observed.
对11例系统性红斑狼疮（SLE）患者肾活检的低温恒温器组织切片中浸润肾脏的单核细胞谱系和分布进行了研究。使用异源抗血清和单克隆抗体已揭示：SLE肾脏标本中几乎不存在B淋巴细胞和浆细胞；浸润间质的绝大多数单核细胞是呈现辅助性（Leu 3 +）表型的活化（HLA-Dr +）T细胞（Leu 4 +）；肾小球中不存在T细胞，在肾小球中可观察到具有巨噬细胞样外观的HLA-Dr +、SIgM -、Leu 4 -成分。
