Olaisen B, Teisberg P, Jonassen R, Gedde-Dahl T, Moen T, Thorsby E
Hum Immunol. 1981 May;2(3):247-54. doi: 10.1016/0198-8859(81)90016-1.
We report genetic studies of families with defined crossovers in the HLA complex. Haplotypic associations between the different alleles have been analyzed. The object of the studies has been to determine the precise location of complement loci on the HLA complex on chromosome 6. Based on direct observation of recombinations and on indirect evidence from haplotypes, we postulate that the C4 and Bf loci are located between the HLA-B and -D regions and probably closer to the former. Available information also points towards the same localization for the C2 locus.
我们报告了对HLA复合体中具有明确交叉的家族的遗传学研究。分析了不同等位基因之间的单倍型关联。这些研究的目的是确定6号染色体上HLA复合体上补体基因座的精确位置。基于对重组的直接观察和来自单倍型的间接证据，我们推测C4和Bf基因座位于HLA - B和 - D区域之间，可能更靠近前者。现有信息也表明C2基因座具有相同的定位。
