成人类风湿关节炎中6号染色体的扩展单倍型
Extended haplotypes of chromosome 6 in adult rheumatoid arthritis.
作者信息
Raum D, Awdeh Z, Glass D, Kammer G, Khan M A, Coblyn J S, Weinblatt M, Holdsworth D, Strong L, Rossen R D
出版信息
Arthritis Rheum. 1984 May;27(5):516-21. doi: 10.1002/art.1780270506.
In 46 patients with rheumatoid arthritis (RA) the allele C4B3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P less than 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA-B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B3: HLA-B15, DR4, BFS, C2C, C4A3, C4B3, was found twice (P less than 0.001) among whites with the disease-associated chromosomes.
在46例类风湿关节炎（RA）患者中，等位基因C4B3出现在6例患者中，而在350名正常对照中出现了6次（P<0.00002）。在9个白人家庭和1个黑人家庭中，每个家庭有2名或更多成员患有RA，共有36种与RA相关的单倍型。在患有疾病相关染色体的白人中，发现一种包含C4B3的扩展单倍型（特定的HLA - B、DR、补体型单倍型处于显著连锁不平衡状态）：HLA - B15、DR4、BFS、C2C、C4A3、C4B3，出现了两次（P<0.001）。
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