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补体成分6(C6)和9(C9)的人类基因在5号染色体上紧密连锁。

The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5.

作者信息

Rogne S, Myklebost O, Olving J H, Kyrkjebø H T, Jonassen R, Olaisen B, Gedde-Dahl T

机构信息

Department of Animal Science, Agricultural University, Norway.

出版信息

J Med Genet. 1991 Sep;28(9):587-90. doi: 10.1136/jmg.28.9.587.

DOI:10.1136/jmg.28.9.587
PMID:1683409
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1015787/
Abstract

We have used a cDNA probe for human complement component 9 (C9), which detects three DNA polymorphisms, to analyse the inheritance of C9 in families informative for C6 protein variants. We found that these genes are closely linked with a lod score of 9.28 at recombination fraction 0.00. There is not indication of allelic association.

摘要

我们使用了一种针对人补体成分9(C9)的cDNA探针,该探针可检测到三种DNA多态性,以分析C6蛋白变体信息丰富的家族中C9的遗传情况。我们发现这些基因紧密连锁,在重组率为0.00时,连锁值为9.28。没有等位基因关联的迹象。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efcc/1015787/529582874a29/jmedgene00035-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efcc/1015787/529582874a29/jmedgene00035-0014-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/efcc/1015787/529582874a29/jmedgene00035-0014-a.jpg

相似文献

1
The human genes for complement components 6 (C6) and 9 (C9) are closely linked on chromosome 5.补体成分6(C6)和9(C9)的人类基因在5号染色体上紧密连锁。
J Med Genet. 1991 Sep;28(9):587-90. doi: 10.1136/jmg.28.9.587.
2
DNA polymorphisms and linkage relationship of the human complement component C6, C7, and C9 genes.人类补体成分C6、C7和C9基因的DNA多态性及连锁关系
Immunogenetics. 1991;33(3):184-7. doi: 10.1007/BF01719238.
3
Genetic detection of the silent allele (*Q0) in hereditary deficiencies of the human complement C6, C7, and C9 components.人类补体C6、C7和C9成分遗传性缺陷中沉默等位基因(*Q0)的基因检测。
Am J Med Genet. 1995 Feb 13;55(4):408-13. doi: 10.1002/ajmg.1320550405.
4
A physical map of the human complement component C6, C7, and C9 genes.人类补体成分C6、C7和C9基因的物理图谱。
Immunogenetics. 1993;38(5):341-4. doi: 10.1007/BF00210475.
5
MspI polymorphism at the human complement component C6 gene (C6).人类补体成分C6基因(C6)的MspI多态性
Nucleic Acids Res. 1991 Jan 11;19(1):194. doi: 10.1093/nar/19.1.194.
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The human complement C9 gene: identification of two mutations causing deficiency and revision of the gene structure.人类补体C9基因:导致缺陷的两种突变的鉴定及基因结构的修正
J Immunol. 1997 May 15;158(10):5043-9.
7
TaqI polymorphism at the human complement component C9 gene.人类补体成分C9基因的TaqI多态性
Nucleic Acids Res. 1990 Sep 25;18(18):5581. doi: 10.1093/nar/18.18.5581.
8
Association of a 12.5-kilobase allele of the MspI restriction fragment length polymorphism of the C6 gene in patients with total deficiency of the sixth component of complement.补体第六成分完全缺乏患者中C6基因MspI限制性片段长度多态性的12.5千碱基等位基因的关联。
Exp Clin Immunogenet. 1993;10(1):38-44.
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Reference typing report for complement components C6, C7 and C9 including mutations leading to deficiencies.补体成分C6、C7和C9的参考分型报告,包括导致缺陷的突变。
Exp Clin Immunogenet. 1998;15(4):268-85. doi: 10.1159/000019082.
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Multiple RFLPs of human complement component nine (C9) detected by TaqI.用TaqI检测到的人类补体成分9(C9)的多个限制性片段长度多态性。
Nucleic Acids Res. 1990 May 25;18(10):3112. doi: 10.1093/nar/18.10.3112-a.

引用本文的文献

1
A physical map of the human complement component C6, C7, and C9 genes.人类补体成分C6、C7和C9基因的物理图谱。
Immunogenetics. 1993;38(5):341-4. doi: 10.1007/BF00210475.
2
C7 M/N protein polymorphism typing applied to inherited deficiencies of human complement proteins C6 and C7.应用于人类补体蛋白C6和C7遗传性缺陷的C7 M/N蛋白多态性分型
Clin Exp Immunol. 1992 Sep;89(3):485-9. doi: 10.1111/j.1365-2249.1992.tb06985.x.

本文引用的文献

1
Further scoring types in sequential linkage tests, with a critical review of autosomal and partial sex linkage in man.序列连锁测试中的进一步计分类型,兼对人类常染色体和部分性连锁的批判性综述。
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Sequential tests for the detection of linkage.用于检测连锁的序贯检验。
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3
Assignment of the structural gene for the third component of human complement to chromosome 19.人类补体第三成分结构基因定位于19号染色体。
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4
Complement loci of the HLA complex. Studies on families with intra-HLA crossovers and haplotype associations.HLA复合体的补体基因座。对具有HLA内部交叉和单倍型关联的家系的研究。
Hum Immunol. 1981 May;2(3):247-54. doi: 10.1016/0198-8859(81)90016-1.
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The sequence and topology of human complement component C9.人类补体成分C9的序列与拓扑结构
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Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.载脂蛋白多基因家族:人载脂蛋白AI、CIII和AIV基因的串联排列
Proc Natl Acad Sci U S A. 1985 Oct;82(19):6374-8. doi: 10.1073/pnas.82.19.6374.
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Report of the Committee on Methods of Linkage Analysis and Reporting.连锁分析与报告方法委员会报告
Cytogenet Cell Genet. 1985;40(1-4):356-9. doi: 10.1159/000132186.
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The membrane attack complex of complement.补体膜攻击复合物
Annu Rev Immunol. 1986;4:503-28. doi: 10.1146/annurev.iy.04.040186.002443.
10
Perforin. A family of killer proteins.
Nature. 1988 Aug 11;334(6182):475-6. doi: 10.1038/334475a0.