Rybakowski J, Potok E, Strzyzewski W
J Affect Disord. 1981 Mar;3(1):59-64. doi: 10.1016/0165-0327(81)90019-7.
The activity of the lithium--sodium countertransport system in erythrocytes was estimated in 16 control subjects and 28 patients suffering from affective disorders (11 bipolar, 17 unipolar) during depression, mania and remission. In all the patients studied, mean estimates of countertransport were significantly lower during an episode than after remission, with low values occurring more frequently in mania than in depression in bipolar patients. The mean values in patients with affective disorders but who were in remission remained lower than those of control subjects. Lowest values occurred more frequently in patients with bipolar than in those with unipolar illness. the possible physiological significance of reductions in the activity of the lithium--sodium countertransport mechanism in red cells was discussed.
在16名对照受试者以及28名患有情感障碍（11名双相情感障碍患者、17名单相情感障碍患者）的患者处于抑郁、躁狂及缓解期时，对其红细胞中锂 - 钠逆向转运系统的活性进行了评估。在所有研究的患者中，发作期逆向转运的平均评估值显著低于缓解期，双相情感障碍患者中，低值在躁狂期比在抑郁期更频繁出现。处于缓解期的情感障碍患者的平均值仍低于对照受试者。双相情感障碍患者中出现最低值的频率高于单相情感障碍患者。文中讨论了红细胞中锂 - 钠逆向转运机制活性降低可能的生理意义。
