胰腺中免疫反应性神经降压素水平：糖尿病大鼠和小鼠中的升高

Immunoreactive neurotensin levels in pancreas: elevation in diabetic rats and mice.

作者信息

Fernstrom M H, Mirski M A, Carraway R E, Leeman S E

出版信息

Metabolism. 1981 Sep;30(9):853-5. doi: 10.1016/0026-0495(81)90063-9.

Abstract

Neurotensin levels in pancreas, but not other tissues, were increased in diabetic animals. The concentration of pancreatic immunoreactiveneurotensin was 138% higher in streptozotocin-diabetic rats, and 68% higher in genetically diabetic (db/db) mice as compared to their respective control animals. Daily administration of insulin (10-15 IU/kg) to diabetic rats completely reversed this effect, and pancreatic neurotensin levels in these animals returned to control values. These findings suggest that elevated levels of pancreatic neurotensin may contribute to some of the metabolic and hormonal disturbances occurring in diabetes.

摘要

糖尿病动物胰腺中的神经降压素水平升高，但其他组织未出现这种情况。与各自的对照动物相比，链脲佐菌素诱导的糖尿病大鼠胰腺中免疫反应性神经降压素的浓度高出138%，遗传性糖尿病（db/db）小鼠则高出68%。每天给糖尿病大鼠注射胰岛素（10 - 15 IU/kg）可完全逆转这种效应，这些动物的胰腺神经降压素水平恢复到对照值。这些发现表明，胰腺神经降压素水平升高可能是糖尿病中发生的一些代谢和激素紊乱的原因之一。