Trahern C A, Gere J B, Krauth G H, Bigham D A
Am J Cardiol. 1978 Apr;41(4):641-5. doi: 10.1016/0002-9149(78)90811-1.
Serum myosin light chain levels were quantitated with radioimmunoassay in patients admitted to the coronary care unit. In this study there were 29 patients with acute myocardial infarction, 84 with chest pain but without myocardial infarction and 5 with chest pain but with preexisting electrocardiographic abnormalities that could not be interpreted using standard criteria. Values for human cardiac light chains in normal human sera averaged less than 2 ng/ml, and values in the 84 patients without myocardial infarction fell into this category. The 29 patients with myocardial infarction all had elevated light chain concentrations (average 10.9 +/- 1.3 ng/ml; range 4 to 35 ng/ml). In this study there were no false positive or false negative results. Use of this assay has permitted separation of patients with and without myocardial infarction. The assay for cardiac light chains provides a biochemical marker of high sensitivity and specificity that is useful in the diagnosis of infarction.
采用放射免疫分析法对冠心病监护病房收治的患者血清肌球蛋白轻链水平进行定量检测。本研究中有29例急性心肌梗死患者，84例胸痛但无心肌梗死患者，以及5例胸痛但既往有心电图异常且无法用标准标准解释的患者。正常人血清中人类心脏轻链的值平均低于2 ng/ml，84例无心肌梗死患者的值属于此类别。29例心肌梗死患者的轻链浓度均升高（平均10.9±1.3 ng/ml；范围4至35 ng/ml）。本研究中无假阳性或假阴性结果。使用该检测方法能够区分有无心肌梗死的患者。心脏轻链检测提供了一种高灵敏度和特异性的生化标志物，对梗死诊断很有用。
