Vita G, Harris J B
J Neurol Sci. 1981 Sep;51(3):339-54. doi: 10.1016/0022-510x(81)90112-x.
The uptake of 99mTc-methylene diphosphonate into rat skeletal muscle has been studied. Uptake did not occur in normal or denervated muscles. Muscles damaged by exposure to the myotoxin notexin did accumulate label. The toxin causes a severe inflammatory, necrotising myopathy and regeneration normally begins 2-3 days after toxin administration. The uptake of label was maximal at 12-24 h, at which time muscle wet weight and cellular infiltration were also maximal. Label was found in the muscle mitochondria, the invading inflammatory cells and the oedema fluid. Regenerating muscles did not accumulate label. The uptake of label was positively correlated with total muscle calcium up to 24 h after the onset of necrosis, but it was suggested that the changes in the two parameters are not causally related.
已对99m锝 - 亚甲基二膦酸盐在大鼠骨骼肌中的摄取情况进行了研究。正常或去神经支配的肌肉中未发生摄取。暴露于肌毒素诺维毒素而受损的肌肉确实积累了放射性标记物。该毒素会引发严重的炎症性、坏死性肌病，通常在给予毒素后2 - 3天开始再生。放射性标记物的摄取在12 - 24小时达到最大值，此时肌肉湿重和细胞浸润也达到最大值。在肌肉线粒体、侵入的炎症细胞和水肿液中发现了放射性标记物。再生的肌肉未积累放射性标记物。在坏死开始后长达24小时内，放射性标记物的摄取与肌肉总钙含量呈正相关，但有人认为这两个参数的变化并非因果相关。
