Siegel B A, Engel W K, Derrer E C
Neurology. 1977 Mar;27(3):230-8. doi: 10.1212/wnl.27.3.230.
In rats with experimental ischemic myopathy, there was a significant correlation (r = 0.778, p less than 0.001) between muscle uptake of technetium-99m (99mTc) diphosphonate and tissue calcium concentration. In addition, the accumulation of both calcium and 99mTc-diphosphonate in acutely injured muscles was further increased in rats with vitamin D-induced hypercalcemia. Histologic studies demonstrated staining of damaged muscle fibers with alizarin red, indicating the presence of microcrystalline or ultramicrocrystalline calcium salts. Staining of muscle fibers was most intense in the outer marginal zones of individual microscopic infarcts. Our results suggest that the uptake of 99mTc-diphosphonate in acutely damaged skeletal muscle is directly related to the deposition of calcium salts within the injured muscle fibers.
在实验性缺血性肌病大鼠中，肌肉对锝-99m（99mTc）二膦酸盐的摄取与组织钙浓度之间存在显著相关性（r = 0.778，p < 0.001）。此外，维生素D诱导的高钙血症大鼠急性损伤肌肉中钙和99mTc-二膦酸盐的蓄积进一步增加。组织学研究显示，受损肌纤维用茜素红染色，表明存在微晶或超微晶钙盐。肌纤维染色在单个显微镜下梗死灶的外缘区域最为强烈。我们的结果表明，急性损伤骨骼肌中99mTc-二膦酸盐的摄取与受损肌纤维内钙盐的沉积直接相关。
