Nogales F F, Matilla A, Carrascal E
Am J Clin Pathol. 1978 Apr;69(4):452-7. doi: 10.1093/ajcp/69.4.452.
Electron microscopic features of the eighth documented case of leiomyomatosis peritonealis disseminata identify the main proliferative cell type as a mature leiomyocyte with all its associated ultrastructural features. The histogenesis of this neoplasm is considered to be a multicentric metaplastic change determined by an abnormal tissue response to the elevated hormonal levels occurring in pregnancy or ovarian functioning tumors. It is suggested that the cell of origin is the multipotent subcelomic mesenchymal cell, which retains the capacity to differentiate into several tissues, among them smooth muscle. To illustrate this possibility, myofibroblasts, cells with hybrid characters of fibroblasts and leiomyocytes, were observed; these may represent a transitional stage between the mesenchymal cell and the smooth muscle proliferating cell.
第八例播散性腹膜平滑肌瘤病的电子显微镜特征显示，主要增殖细胞类型为成熟的平滑肌细胞及其所有相关的超微结构特征。该肿瘤的组织发生被认为是一种多中心化生改变，由妊娠或卵巢功能性肿瘤中激素水平升高时异常的组织反应所决定。有人提出，起源细胞是多能的间皮间充质细胞，它保留了分化为几种组织的能力，其中包括平滑肌。为了说明这种可能性，观察到了肌成纤维细胞，即具有成纤维细胞和平滑肌细胞混合特征的细胞；这些细胞可能代表了间充质细胞和平滑肌增殖细胞之间的过渡阶段。
