Kuo T, London S N, Dinh T V
Am J Surg Pathol. 1980 Apr;4(2):197-204. doi: 10.1097/00000478-198004000-00012.
Leiomyomatosis peritonealis disseminata is a pseudomalignant condition which mimics disseminated abdominal carcinoma. A new case is reported and compared to the 11 well-documented cases in the literature. All reported patients have experienced a benign clinical course. The peritoneal nodules are composed of histologically benign-appearing smooth-muscle cells, substantiated by electron-microscopic study. The histogenesis of this entity is discussed in the light of our ultrastructural findings and the observation of concurrent endometriosis. The theory of metaplasia of the subcoelomic mesenchyme in the pathogenesis of the leiomyomatous lesions is favored. The serum estrogen levels determined in our patient did not reveal any abnormal change. The inducing factor(s) remain to be identified. Also, an unusual sensitivity of the coelomic tissues in these patients, in response to metaplastic stimuli, is postulated as a possible contributing factor.
播散性腹膜平滑肌瘤病是一种类似播散性腹部癌的假性恶性疾病。本文报告了一例新病例，并与文献中11例有充分记录的病例进行了比较。所有报告的患者均经历了良性临床过程。腹膜结节由组织学上看似良性的平滑肌细胞组成，电镜研究证实了这一点。根据我们的超微结构发现以及同时存在子宫内膜异位症的观察结果，对该实体的组织发生进行了讨论。平滑肌瘤样病变发病机制中体腔下间充质化生的理论更受青睐。我们患者的血清雌激素水平未显示任何异常变化。诱导因素仍有待确定。此外，推测这些患者体腔组织对化生刺激具有异常敏感性可能是一个促成因素。
