Miyamoto K, Hamasaki K, Kitajima K, Adachi T, Tanaka T, Sato J
Acta Med Okayama. 1981 Apr;35(2):137-41. doi: 10.18926/AMO/31265.
Partial excess of chromosome 1 (q25-q32) was noted in malignant cells from all of 10 patients who had disorders such as non-African Burkitt's lymphoma, adult T-cell leukemia, myelofibrosis, malignant lymphoma, chronic lymphocytic leukemia or chronic myelocytic leukemia in blast crisis. The break points on chromosome 1 were at centromere, q12, q21, q23, q25 and q32. Variations in the specific region of the long arm of chromosome 1, q25-q32, were thought to be important in the evolution of malignant cell proliferation.
在患有非非洲伯基特淋巴瘤、成人T细胞白血病、骨髓纤维化、恶性淋巴瘤、慢性淋巴细胞白血病或处于急变期的慢性粒细胞白血病等疾病的10例患者的恶性细胞中，均发现了1号染色体（q25-q32）部分片段过量。1号染色体的断点位于着丝粒、q12、q21、q23、q25和q32处。1号染色体长臂的特定区域q25-q32的变异被认为在恶性细胞增殖演变过程中具有重要作用。
