Nwoye L, Mommaerts W F
J Muscle Res Cell Motil. 1981 Sep;2(3):307-20. doi: 10.1007/BF00713269.
The effects of different thyroid states on some histochemical and biochemical properties of fast-twitch muscle were studied using rat extensor digitorum longus (EDL) muscle. This muscle was found to be much less responsive to thyroidal influence than the slow-twitch soleus muscle. In EDL muscles of hypothyroid rats, fast leads to slow conversions were observed in fibre type composition, myosin ATPase activity and light chain pattern, and in the subunit composition of lactate dehydrogenase, while the only significant slow leads to fast conversion observed in thyrotoxicosis was a decrease in the proportion of slow-oxidative fibres. Denervation of the hypothyroid muscle produced the highest degree of fast leads to slow transformation. These findings support the view that denervation and dysthyreosis alter gene expression in muscle by independent mechanisms.
利用大鼠趾长伸肌（EDL）研究了不同甲状腺状态对快肌某些组织化学和生化特性的影响。结果发现，该肌肉对甲状腺影响的反应远低于慢肌比目鱼肌。在甲状腺功能减退大鼠的EDL肌肉中，观察到纤维类型组成、肌球蛋白ATP酶活性和轻链模式以及乳酸脱氢酶亚基组成从快向慢的转变，而在甲状腺毒症中观察到的唯一显著的从慢向快的转变是慢氧化纤维比例的降低。甲状腺功能减退肌肉的去神经支配导致了从快到慢转变的最高程度。这些发现支持了去神经支配和甲状腺功能异常通过独立机制改变肌肉基因表达的观点。
