Gasparian E I
Zh Nevropatol Psikhiatr Im S S Korsakova. 1981;81(7):981-4.
Under conditions of experimentally induced thyroid insufficiency a number of structural changes were revealed in the brain tissues and the pia mater. Of a particular importance among them were changes in the vessels of the microcirculation system that manifested themselves in the form of disturbed metabolism of acidic mucopolysaccharides with their accumulation and polymerization in the course of hypothyroidism, as well as accumulation of biogenic monoamines (noradrenaline and serotonin) in the endothelium of the precapillary arterioles and capillaries. The changes discovered may be taken as a basis for the explanation of some neurological and especially vascular manifestations on the part of the nervous system in patients with hypothyroidism.
在实验性诱导甲状腺功能不全的情况下，脑组织和软脑膜出现了一些结构变化。其中特别重要的是微循环系统血管的变化，其表现为酸性粘多糖代谢紊乱，在甲状腺功能减退过程中积累并聚合，以及生物源性单胺（去甲肾上腺素和5-羟色胺）在毛细血管前小动脉和毛细血管内皮中的积累。所发现的这些变化可作为解释甲状腺功能减退患者神经系统部分神经学表现尤其是血管表现的基础。
