沙丁胺醇、异丙托溴铵和色甘酸钠对正常受试者运动诱发的气喘的影响。
Effects of salbutamol, ipratropium bromide and disodium cromoglycate on breathlessness induced by exercise in normal subjects.
作者信息
Stark R D, Gambles S A
出版信息
Br J Clin Pharmacol. 1981 Oct;12(4):497-501. doi: 10.1111/j.1365-2125.1981.tb01256.x.
Abstract
1 Healthy volunteers undertook submaximal graded exercise while objective measurements of cardio-respiratory function were made and breathlessness was assessed with serial visual analogue scales. 2 A useful and consistent relationship existed between breathlessness and ventilation for individual subjects. 3 Drugs were examined in this system to test whether they modified the relationship between ventilation and breathlessness such that less breathlessness occurred for a given level of ventilation. 4 Salbutamol, ipratropium bromide and disodium cromoglycate given by inhalation did not reduce breathlessness in healthy subjects during exercise.
摘要
- 健康志愿者进行了次极量分级运动，同时对心肺功能进行了客观测量，并使用系列视觉模拟量表评估了呼吸困难程度。2. 对于个体受试者，呼吸困难与通气之间存在有用且一致的关系。3. 在该系统中对药物进行了检测，以测试它们是否改变了通气与呼吸困难之间的关系，从而在给定的通气水平下使呼吸困难减轻。4. 吸入沙丁胺醇、异丙托溴铵和色甘酸钠并不能减轻健康受试者运动期间的呼吸困难。
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