Mitchell-Heggs P, Murphy K, Minty K, Guz A, Patterson S C, Minty P S, Rosser R M
Q J Med. 1980 Winter;49(193):9-20.
Diazepam, in moderate doses, has been used in a placebo controlled, single blind study to treat dyspnoea in four patients severely disabled from chronic airflow obstruction. The subjects had the 'pink puffer syndrome', usually associated with emphysema and were not hypercapnoeic nor severely hypoxic at rest. With diazepam, they experienced a striking reduction in dyspnoea, and an improvement in effort tolerance; in addition the slope of the ventilation/CO2 response curve was reduced. There were no changes in resting blood gases. Psychiatric examination at the end of the study did not reveal prominent anxiety, although three patients were depressed. The use of diazepam to treat dyspnoea in this syndrome is safe in the absence of any acute infection
在一项安慰剂对照的单盲研究中，使用中等剂量的地西泮治疗4例因慢性气流阻塞而严重致残的患者的呼吸困难。这些受试者患有通常与肺气肿相关的“粉色肺大泡综合征”，静息时不存在高碳酸血症，也没有严重缺氧。使用地西泮后，他们的呼吸困难明显减轻，耐力有所改善；此外，通气/二氧化碳反应曲线的斜率降低。静息血气没有变化。研究结束时的精神检查未发现明显焦虑，尽管有3例患者存在抑郁。在没有任何急性感染的情况下，使用地西泮治疗该综合征的呼吸困难是安全的。
