色甘酸钠对麻醉犬组胺气雾剂诱发的反射性支气管收缩的影响。
The effects of sodium cromoglycate on histamine aerosol-induced reflex bronchoconstriction in the anaesthetized dog.
作者信息
Jackson D M, Richards I M
出版信息
Br J Pharmacol. 1977 Oct;61(2):257-62. doi: 10.1111/j.1476-5381.1977.tb08413.x.
Abstract
1 The effects have been studied of sodium cromoglycate (SCG), given by aerosol or intravenously, on reflex bronchoconstriction induced by histamine aerosol in the anaesthetized dog. 2 Four breaths of an aerosol generated from a 2% solution of SCG significantly inhibited the vagally mediated increase in total lung resistance (RL) produced by histamine. 3 SCG given intravenously as bolus injections (5-500 microgram/kg) produced a dose-dependent reversal of a sustained reflex bronchoconstriction induced by histamine aerosol. Propranolol (500 microgram/kg) did not prevent this reversal. 4 SCG did not inhibit the increase in RL produced by supramaximal electrical stimulation of a vagus nerve. 5 The possibility is discussed that SCG may reduce the activity of lung irritant receptors in the anaesthetized dog.
摘要
- 已对雾化或静脉注射色甘酸钠（SCG）对麻醉犬组胺雾化诱发的反射性支气管收缩的影响进行了研究。2. 来自2% SCG溶液产生的雾化剂的四次呼吸显著抑制了组胺引起的迷走神经介导的总肺阻力（RL）增加。3. 静脉推注SCG（5 - 500微克/千克）产生了组胺雾化诱发的持续性反射性支气管收缩的剂量依赖性逆转。普萘洛尔（500微克/千克）并未阻止这种逆转。4. SCG并未抑制迷走神经超最大电刺激引起的RL增加。5. 讨论了SCG可能降低麻醉犬肺刺激感受器活性的可能性。
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