Godorozha P D, Zabezhinskiĭ M A, Okulov V B, Puchkov Iu G, Pliss G B
Biull Eksp Biol Med. 1981 Sep;92(9):347-9.
Methylcholanthrene solution was applied to the lower lip mucosa of 110 CC57 BR male mice during 2 months. Simultaneously with or after methylcholanthrene application part of mice was injected into the lower lip with ethanolic extract of rat skin containing epidermal G1 and G2 chalones. The remaining mice were injected with liver chalones or were left intact. Administration of the epidermal chalone produced the tumor growth retention, and the increased frequency of tumour regression, promoted tumor differentiation and decreased tumor invasion. The results indicate the possibility of using chalones as inhibitors of tumor growth.
在2个月的时间里，将甲基胆蒽溶液涂抹于110只CC57 BR雄性小鼠的下唇黏膜。在涂抹甲基胆蒽的同时或之后，部分小鼠被注射含有表皮G1和G2抑素的大鼠皮肤乙醇提取物至下唇。其余小鼠则注射肝脏抑素或不做处理。表皮抑素的施用导致肿瘤生长停滞、肿瘤消退频率增加、促进肿瘤分化并减少肿瘤侵袭。结果表明使用抑素作为肿瘤生长抑制剂的可能性。
