[表皮抑素对可移植肿瘤生长的影响]
[Effect of epidermal chalones on the growth of transplantable tumors].
作者信息
Okulov V B, Anisimov V N, Azarova M A
出版信息
Biull Eksp Biol Med. 1977 Oct;84(10):466-8.
The ethanolic extract of rat skin contains epidermal G1- and G2-chalones which having been added to cell suspension of transplantable squamous-cell cornified carcinoma of mice cervix, inhibits its growth in recipients by 72,6 per cent. The same extract failed to inhibit the growth of transplantable mouse tumours of other histogenesis (hepatoma 22a, leukemia L-1210 and sarcoma 180). When added to cell suspension of transplantable carcinoma of mouse skin which had been anaplized during a long period of transplantation (over 10 years) this extract inhibits its growth by 39,2 per cent only.
大鼠皮肤的乙醇提取物含有表皮G1和G2抑素，将其添加到小鼠宫颈可移植鳞状细胞角化癌的细胞悬液中，可使受体中的肿瘤生长抑制72.6%。相同提取物未能抑制其他组织发生类型的可移植小鼠肿瘤（肝癌22a、白血病L-1210和肉瘤180）的生长。当将该提取物添加到在长期移植（超过10年）过程中发生间变的小鼠皮肤可移植癌的细胞悬液中时，仅使其生长抑制39.2%。
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