Bitter K
J Maxillofac Surg. 1976 Dec;4(4):226-31. doi: 10.1016/s0301-0503(76)80043-4.
Bleomycin was traced by the isotope Cobalt-57. By using this radioactive substance the pharmacokinetic behaviour of the drug was examined. It was given either intravenously or intra-arterially or directly into the tumor in patients suffering from epidermoid carcinoma in the maxillo-facial region. The differences in the pharmacokinetic data are delineated. Practically, the intra-arterial route of administration is the best one because of the high adherence rate of the drug to the perfused tissue.
用同位素钴 - 57追踪博来霉素。通过使用这种放射性物质，研究了该药物的药代动力学行为。在患有颌面区域表皮样癌的患者中，通过静脉内、动脉内或直接注入肿瘤的方式给予该药物。描述了药代动力学数据的差异。实际上，动脉内给药途径是最佳途径，因为该药物对灌注组织的附着率很高。
