高渗尿素用于中期选择性流产。1913例经验

Hyperosmolar urea for elective midtrimester abortion. Experience in 1,913 cases.

作者信息

Burkman R T, Atienza M F, King T M, Tonascia J A, Pang J C, Whitmore A J

出版信息

Am J Obstet Gynecol. 1978 May 1;131(1):10-7. doi: 10.1016/0002-9378(78)90467-2.

Abstract

Intra-amniotic hyperosmolar urea (59.7 per cent) augmented by intravenous oxytocin (332 millimicron per minute), prostaglandin F2alpha (20 mg.), prostaglandin F2alpha (10 mg.), or prostaglandin F2alpha (5 mg.) was utilized for 1,913 patients requesting elective midtrimester abortion. Injection-abortion intervals ranging from 13.70 to 21.49 hours were achieved with failure rates of 0.7 to 6.7 per cent. Despite frequent pre-existing medical conditions, the complication rate compared favorably with those of other methods for terminating midtrimester pregnancy such as saline amnioinfusion or dilatation and evacuation.

摘要

羊膜腔内高渗尿素（59.7%）联合静脉滴注缩宫素（每分钟332毫微克）、前列腺素F2α（20毫克）、前列腺素F2α（10毫克）或前列腺素F2α（5毫克），用于1913例要求选择性中期妊娠流产的患者。注射流产间隔时间为13.70至21.49小时，失败率为0.7%至6.7%。尽管常有既往病史，但与其他中期妊娠终止方法（如生理盐水羊膜腔灌注或扩张刮宫）相比，并发症发生率较低。