Klinga K, Bek E, Runnebaum B
Am J Obstet Gynecol. 1978 May 1;131(1):60-2. doi: 10.1016/0002-9378(78)90474-x.
Peripheral serum testosterone levels were determined in 180 women during weeks 7 to 20 of pregnancy with a specific radioimmunoassay. After a normal pregnancy and delivery 90 serum samples were randomly selected from mothers of boys and 90 serum samples from mothers of girls. The testosterone concentrations were correlated with the sex of the fetuses. The mean testosterone level +/- S.D. in pregnant women with female fetuses was 597 +/- 167 pg. per milliliter. In pregnant women with male fetuses the testosterone concentrations were on the average significantly higher (p less than 0.01), with a mean value of 828 +/- 298 pg. per milliliter. The course of the testosterone concentrations in women with male fetuses showed an increase beginning in week 7, reaching a maximum during weeks 9 to 11, followed by a decrease until weeks 15 to 20. During weeks 9 to 11 of pregnancy fetal sex determination was possible in 28 per cent of the males and in 5 per cent of the females, with a probability of 95.5 per cent.
采用特异性放射免疫分析法测定了180名孕妇在妊娠第7至20周外周血清睾酮水平。在正常妊娠和分娩后，从生男婴母亲的血清样本中随机选取90份，从生女婴母亲的血清样本中随机选取90份。将睾酮浓度与胎儿性别进行关联分析。怀有女胎的孕妇血清睾酮平均水平±标准差为每毫升597±167皮克。怀有男胎的孕妇血清睾酮浓度平均显著更高（p＜0.01），平均值为每毫升828±298皮克。怀有男胎的女性睾酮浓度变化过程显示，从第7周开始升高，在第9至11周达到最高值，随后下降直至第15至20周。在妊娠第9至11周期间，28%的男胎和5%的女胎能够进行胎儿性别判定，概率为95.5%。
