Glass A R, Klein T
Am J Obstet Gynecol. 1981 Jul 15;140(6):656-60. doi: 10.1016/0002-9378(81)90199-x.
The fetal testis actively produces androgens during early gestation. To determine whether this fetal production of androgens might be reflected by levels of androgens in maternal serum, which might then be a useful test for antenatal fetal sex determination, we measured serum testosterone (total and free) and serum dihydrotestosterone in 83 pregnant women whose fetuses ranged from 4 to 20 weeks in age. For no maternal serum androgen measured was there a significant difference between women carrying a male fetus and those carrying a female fetus, even when this comparison was limited to various 4-week subintervals or fetal age. Total serum testosterone correlated directly with fetal age (r = 0.341, p less than 0.005), but serum dihydrotestosterone did not (r = 0.146, p = NS). Inverse correlations with fetal age were observed for percentage free testosterone (r = -0.531, p less than 0.001) as well as absolute serum free testosterone (r = -0.349, p less than 0.005). We conclude that maternal serum androgen levels are not useful for antenatal fetal sex determination in early pregnancy. The reason for the progressive fall in serum free testosterone, and presumably androgen production, during early gestation remains obscure.
在妊娠早期，胎儿睾丸会活跃地产生雄激素。为了确定母体血清中的雄激素水平是否能反映胎儿产生的雄激素，以及这是否可能成为一种有用的产前胎儿性别鉴定检测方法，我们测量了83名孕妇血清中的睾酮（总睾酮和游离睾酮）以及双氢睾酮，这些孕妇的胎儿年龄在4至20周之间。对于所测量的任何一种母体血清雄激素，怀有男胎的女性和怀有女胎的女性之间均无显著差异，即使这种比较仅限于不同的4周时间段或胎儿年龄。血清总睾酮与胎儿年龄直接相关（r = 0.341，p < 0.005），但血清双氢睾酮并非如此（r = 0.146，p =无显著性差异）。游离睾酮百分比（r = -0.531，p < 0.001）以及血清游离睾酮绝对值（r = -0.349，p < 0.005）与胎儿年龄呈负相关。我们得出结论，母体血清雄激素水平对妊娠早期的产前胎儿性别鉴定并无用处。妊娠早期血清游离睾酮以及推测的雄激素产生逐渐下降的原因仍不清楚。
