Eskenasy A
Morphol Embryol (Bucur). 1981 Apr-Jun;27(2):147-53.
Experimentally induced lung granulomas of rabbits challenged by complete Freund's adjuvant with human gammaglobulins were ultrastructurally studied at two moments of their evolution: 10 and 20 days. Granulomas were formed even in the first stage, being composed of histiocytic accumulations around capillaries, sometimes dilated, in which the adjuvant lipidic compounds were embolized: hypertrophy of endothelial cytoplasms, lymphocytic insertions with membrane contacts with the histiocytes, an epithelial covering completed this picture. The 20-day granulomas presented intragranulomatous capillaries with hypertrophied endothelia, macrophages and lymphocytes; the pericapillary granulomatous tissue showed many epithelioid cells with mitochondria and numerous cytoplasmic vesicles of different densities (among them "grey vesicles"), and long cytoplasmic digitations; some histiocytes had an epithelioid aspect. A large granulous alveolocyte was sometimes present at the granuloma periphery. The perinodular veins evinced hypertrophied endothelia with many pinocytotic vesicles and coated caveolae expressing the processing of engulfed transported particles; fibroblasts were active near veins.
用完全弗氏佐剂与人丙种球蛋白对家兔进行攻击，从而实验性诱导出肺部肉芽肿，在肉芽肿演变的两个阶段（10天和20天）对其进行了超微结构研究。在第一阶段就形成了肉芽肿，由围绕毛细血管的组织细胞聚集构成，毛细血管有时扩张，其中佐剂脂质化合物形成栓子：内皮细胞质肥大，淋巴细胞嵌入并与组织细胞有膜接触，上皮覆盖完善了这一景象。20天的肉芽肿呈现出肉芽肿内毛细血管，其内皮、巨噬细胞和淋巴细胞肥大；毛细血管周围的肉芽肿组织有许多上皮样细胞，含有线粒体和许多不同密度的细胞质小泡（包括“灰色小泡”），还有长的细胞质指状突起；一些组织细胞呈上皮样外观。在肉芽肿周边有时可见一个大的颗粒状肺泡细胞。结节周围静脉的内皮肥大，有许多胞饮小泡和包被小窝，表明正在处理吞噬转运的颗粒；成纤维细胞在静脉附近活跃。
