Eskenasy A, Popescu E
Department of Experimental Pathology, Tuberculosis Research Institute, Bucharest, Romania.
Med Interne. 1982 Oct-Dec;20(4):299-306.
The stereotyped evolution toward fibrosis of lung granulomas induced in rabbits by an intravenous injection of the complete Freund adjuvant was analysed under the influence of a prolonged treatment with cyclophosphamide. While the histopathological picture of untreated rabbits showed a progressive evolution toward fibrosis of experimental lung granulomas, cyclophosphamide administration (1.5 mg/kg body, daily for three weeks) reduced the number of granuloma cells on the surface unit and the density of reticulin fibrils up to statistically significant values.
分析了静脉注射完全弗氏佐剂诱导兔肺部肉芽肿向纤维化的定型演变过程，观察了长期使用环磷酰胺治疗对此演变的影响。未治疗兔的组织病理学表现为实验性肺肉芽肿逐渐向纤维化发展，而给予环磷酰胺（1.5mg/kg体重，每日一次，共三周）可使单位面积表面的肉芽肿细胞数量及网状纤维密度降低，且降低程度具有统计学意义。
